Bilancio Familiare Excel Ware For Ipad more. Direct Compression is the simplest form of oral dosage production as it contains the fewest process stages, leading to a shorter process cycle and faster production. Direct Compression is the simplest form of oral dosage production as it contains the fewest process stages, leading to a shorter process cycle and faster production. A comparative evaluation of direct compression and wet. Direct compression method as per the formulae given in Tables 1. All the materials required as per the. Direct compression is a popular choice because it provides the shortest, most effective and least complex way to produce tablets. The manufacturer can blend an API.

IntroductionIn early days, most of the tablets require granulation of the powdered Active Pharmaceutical Ingredient (API) and Excipients. At the availability of new excipients or modified form of old excipients and the invention of new tablet machinery or modification of old tablet machinery provides an ease in manufacturing of tablets by simple procedure of direct compression. Amongst the techniques used to prepare tablets, direct compression is the most advanced technology. It involves only blending and compression. Thus offering advantage particularly in terms of speedy production. Because it requires fewer unit operations, less machinery, reduced number of personnel and considerably less processing time along with increased product stability. Definition: The term “direct compression” is defined as the process by which tablets are compressed directly from powder mixture of API and suitable excipients.

No pretreatment of the powder blend by wet or dry granulation procedure is required. The events that motivates the industry people to use direct compression techniqueI.Commercial availability of the directly compressible excipients possessing both good compressibility and good flowability. For example, Spray dried lactose, Anhydrous lactose, Starch-1500, microcrystalline cellulose, Di-Pac, Sorbitol II. Major advances in tablet compression machinery, i) Improved positive die feeding ii) Precompression of powder blend Meritsi)Direct compression is more efficient and economical process as compared to other processes, because it involves only dry blending and compaction of API and necessary excipients. Ii)The most important advantage of direct compression is economical process.Reduced processing time, reduced labor costs, fewer manufacturing steps, and less number of equipments are required, less process validation, reduced consumption of power.

Iii)Elimination of heat and moisture, thus increasing not only the stability but also the suitability of the process for thermolabile and moisture sensitive API’s. Iv)Particle size uniformity. V)Prime particle dissolution. In case of directly compressed tablets after disintegration, each primary drug particle is liberated.

While in the case of tablets prepared by compression of granules, small drug particles with a larger surface area adhere together into larger agglomerates; thus decreasing the surface area available for dissolution. Vi)The chances of batch-to-batch variation are negligible, because the unit operations required for manufacturing processes is fewer. Vii)Chemical stability problems for API and excipient would be avoided. Viii)Provides stability against the effect of aging which affects the dissolution rates. Merits over wet granulation processThe variables faced in the processing of the granules can lead to significant tableting problems. Properties of granules formed can be affected by viscosity of granulating solution, the rate of addition of granulating solution, type of mixer used and duration of mixing, method and rate of dry and wet blending. The above variables can change the density and the particle size of the resulting granules and may have a major influence on fill weight and compaction qualities.